Product Information：
- Product name: ALIENTRECTINIB Entrectinib 100mg
- Manufacturer / brand: Laos Alliance
- Active ingredient: Entrectinib
- Current strength: 100mg
- SKU: 11-L-1229
- Site category: general medicines, NTRK target, ROS1 target
Active Ingredient and Reference Data
Entrectinib is the active ingredient used for this product page. Public prescribing information for Entrectinib was used for the medical reference sections. Medical details are provided for reference and must be interpreted by a qualified healthcare professional.
Mechanism of Action
Entrectinib is an inhibitor of the tropomyosin receptor tyrosine kinases (TRK) TRKA, TRKB, and TRKC (encoded by the neurotrophic tyrosine receptor kinase [ NTRK ] genes NTRK1, NTRK2, and NTRK3 , respectively), proto-oncogene tyrosine-protein kinase ROS1 (ROS1), and anaplastic lymphoma kinase (ALK) with IC 50 values of 0.1 to 2 nM. Entrectinib also inhibits JAK2 and TNK2 with IC 50 values > 5 nM. The major active metabolite of entrectinib, M5, showed similar in vitro activity against TRK, ROS1, and ALK.
Storage and Purchase Notes
Store according to the package or pharmacist instructions and keep out of reach of children. Before ordering, confirm product name, strength, quantity, price, shipping details, and payment method. After receipt, check packaging, batch number, expiration date, and storage conditions.
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