Product Information：
- Product name: Dabrafenib 75mg
- Manufacturer / brand: Laos Alliance
- Active ingredient: Dabrafenib
- Current strength:75mg
- SKU: 10-L-1222
- Site category: BRAF V600E/V600K target, BRAF V600E target
Active Ingredient and Reference Data
Dabrafenib is the active ingredient used for this product page. Public prescribing information for Dabrafenib was used for the medical reference sections. Medical details are provided for reference and must be interpreted by a qualified healthcare professional.
Mechanism of Action
Dabrafenib is an inhibitor of some mutated forms of BRAF kinases with in vitro IC 50 values of 0.65, 0.5, and 1.84 nM for BRAF V600E, BRAF V600K, and BRAF V600D enzymes, respectively. Dabrafenib also inhibits wild-type BRAF and CRAF kinases with IC 50 values of 3.2 and 5.0 nM, respectively, and other kinases, such as SIK1, NEK11, and LIMK1 at higher concentrations. Some mutations in the BRAF gene, including those that result in BRAF V600E, can result in constitutively activated BRAF kinases that may stimulate tumor cell growth .
Storage and Purchase Notes
Store according to the package or pharmacist instructions and keep out of reach of children. Before ordering, confirm product name, strength, quantity, price, shipping details, and payment method. After receipt, check packaging, batch number, expiration date, and storage conditions.
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