【us：Piqray】Alpelisib 50mg/tablet 28tablets/bottle

Product Information：

• Product name: Alpelisib 50mg
• Manufacturer / brand: Laos Alliance
• Active ingredient: Acalabrutinib
• Current strength: 50mg
• SKU: 07-L-1367
• Site category: PIK3CA target, other cancer

Active Ingredient and Reference Data

Alpelisib is the active ingredient used for this product page. Public prescribing information for Alpelisib was used for the medical reference sections. Medical details are provided for reference and must be interpreted by a qualified healthcare professional.

Mechanism of Action

Alpelisib is an inhibitor of phosphatidylinositol-3-kinase (PI3K) with inhibitory activity predominantly against PI3Kα. Gain-of-function mutations in the gene encoding the catalytic α-subunit of PI3K (PIK3CA) lead to activation of PI3Kα and Akt-signaling, cellular transformation and the generation of tumors in in vitro and in vivo models. Activating mutations in PIK3CA have been found to induce a spectrum of overgrowths and malformations comprising a wide group of clinically recognizable disorders commonly known as PROS. These findings were reversed after withdrawal of alpelisib.

Storage and Purchase Notes

Store according to the package or pharmacist instructions and keep out of reach of children. Before ordering, confirm product name, strength, quantity, price, shipping details, and payment method. After receipt, check packaging, batch number, expiration date, and storage conditions.