Product Information：
- Product name: Ivosidenib 250mg
- Manufacturer / brand: Laos Alliance
- Active ingredient: Ivosidenib
- Current strength: 250mg
- SKU: 07-L-1130
- Site category: cholangiocarcinoma, IDH1 target, other cancer
Active Ingredient and Reference Data
Ivosidenib is the active ingredient used for this product page. Public prescribing information for Ivosidenib was used for the medical reference sections. Medical details are provided for reference and must be interpreted by a qualified healthcare professional.
Mechanism of Action
Ivosidenib is a small molecule inhibitor that targets the mutant isocitrate dehydrogenase 1 (IDH1) enzyme. The most common of such mutations in patients with AML are R132H and R132C substitutions. Ivosidenib was shown to inhibit selected IDH1 R132 mutants at much lower concentrations than wild-type IDH1 in vitro. Inhibition of the mutant IDH1 enzyme by ivosidenib led to decreased 2-HG levels and induced myeloid differentiation in vitro and in vivo in mouse xenograft models of IDH1-mutated AML.
Storage and Purchase Notes
Store according to the package or pharmacist instructions and keep out of reach of children. Before ordering, confirm product name, strength, quantity, price, shipping details, and payment method. After receipt, check packaging, batch number, expiration date, and storage conditions.
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