Product Information：
- Product name: ALILAROTINIB Larotrectinib 100mg
- Manufacturer / brand: Laos Alliance
- Active ingredient: Larotrectinib
- Current strength: 100mg
- SKU: 11-L-1228
- Site category: broad-spectrum anticancer drugs, NTRK target, other cancer
Active Ingredient and Reference Data
Larotrectinib is the active ingredient used for this product page. Public prescribing information for Larotrectinib was used for the medical reference sections. Medical details are provided for reference and must be interpreted by a qualified healthcare professional.
Mechanism of Action
Larotrectinib is an inhibitor of the tropomyosin receptor kinases (TRK), TRKA, TRKB, and TRKC. One other kinase TNK2 was inhibited at approximately 100-fold higher concentration. TRKA, B, and C are encoded by the genes NTRK1, NTRK2, and NTRK3. Chromosomal rearrangements involving in-frame fusions of these genes with various partners can result in constitutively-activated chimeric TRK fusion proteins that can act as an oncogenic driver, promoting cell proliferation and survival in tumor cell lines.
Storage and Purchase Notes
Store according to the package or pharmacist instructions and keep out of reach of children. Before ordering, confirm product name, strength, quantity, price, shipping details, and payment method. After receipt, check packaging, batch number, expiration date, and storage conditions.
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